不同乳化剂对鸦胆子油乳注射液溶血结果的影响

The Optimization of Emulsifiers Considering Their Effects on Hemolysis of Brucea Javanica Oil Emulsion Injection

关键词:  鸦胆子油乳注射液  精制蛋黄卵磷脂  维生素E  溶血试验

Key words:  Brucea javanica oil emulsion injection  refined egg lecithin  vitamine E  hemolytic experimentation

摘要:

目的 考察不同磷脂对鸦胆子油乳注射液溶血结果的影响。方法 通过选择豆磷脂和卵磷脂作乳化剂分别与鸦胆子油制成脂肪乳剂，经过加速试验，经体外溶血试验检查，选择更有利于制备鸦胆子油乳注射液的乳化剂。结果 精制蛋黄卵磷脂作乳化剂可以延长鸦胆子油乳注射液的溶血出现时间，加入维生素E后溶血出现时间会进一步延长。结论 可以用精制蛋黄卵磷脂代替豆磷脂作乳化剂制备鸦胆子油乳注射液。

Abstract:

OBJECTIVE To explore the effects of different phospholipids on the results of hemolytic experimentation in Brucea javanica oil emulsion injection. METHODS The soybean lecithin and lecithin were used as emulsifier, and then make them with Brucea javanica oil, by accelerated examination, chose the best emulsifier based on the results of hemolytic experimentation. RESULTS The refined egg lecithin can extend genesic time of hemolysis. If the oil emulsion contains vitamine E, the genesic time of hemolysis becomes longer. CONCLUSION The refined egg lecithin can replace the soybean lecithin as emulsifier in Brucea javanica oil emulsion injection.