| 引用本文: | 吴云珍,吴宁苹,李文辉.苯磺酸氨氯地平的合成[J].中国现代应用药学,2011,28(2):140-141. |
| WU Yunzhen,WU Ningping,LI Wenhui.Synthesis of Amlodipine Besylate[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(2):140-141. |
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| 摘要: |
| 目的 苯磺酸氨氯地平的合成。方法 通过吡咯衍生物和氨基巴豆酸甲酯和2-氯苯甲醛进行Hantzsch反应获得高收率的氨氯地平。结果 反应总收率在45%以上。目标化合物结构经1H-NMR确证。结论 此工艺方法简便，适合工业化生产。 |
| 关键词: 苯磺酸氨氯地平 抗高血压 二氢吡啶环 合成 |
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| Synthesis of Amlodipine Besylate |
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WU Yunzhen, WU Ningping, LI Wenhui
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Zhejiang Jinhua Conba Bio-pharm Co., Ltd., Jinhua 321016, China
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| Abstract: |
| OBJECTIVE Synthesis of amlodipine besylate. METHODS A high yield of amlodipine can be obtained by performing a Hantzsch reaction of a pyrrole derivative with methyl aminocrotonate and 2-chlorobenzaldehyde. RESULTS The total yield was 45%. The structure of amlodipine was identified by 1H-NMR. CONCLUSION The process can be easily controlled and suitable for a scale production. |
| Key words: amlodipine besylate antihypertnsive dihydropyridine synthesis |
