石墨炉原子吸收法测定盐酸伐昔洛韦中钯的残留量

Palladium Residues Determination in Valaciclovir Hydrochloride by Graphite Furnace Atomic Absorption Spectrometry

关键词:  石墨炉原子吸收分光光度法  钯  盐酸伐昔洛韦

Key words:  graphite furnace atomic absorption spectrometry  palladium  valaciclovir hydrochloride

摘要:

目的 建立盐酸伐昔洛韦中钯残留量的测定方法。方法 采用微波消解系统消解样品，石墨炉原子吸收分光光度法测定盐酸伐昔洛韦中钯的残留量。结果 钯在浓度1.0~30.0 μg·L^-1内呈良好线性关系(r=0.999 5)。检出限为0.20 μg·L^-1，定量限为0.95 μg·L^-1，特征浓度(灵敏度)为0.57 μg·L^-1，平均回收率为101.69%。结论 采用本法测定盐酸伐昔洛韦中钯的残留量灵敏、准确、可靠，为药品质量控制提供依据。

Abstract:

OBJECTIVE To establish a method for the determination of Pd in valaciclovir hydrochloride. METHODS Appling microwave degrading system to deteriorate sample, use a graphite furnace atomic absorption spectrometry (AAS) method to determine Pd residues in valaciclovir hydrochloride. RESULTS It showed a good linear relationship within the concentration range of 1.0-30.0 μg·L^-1(r=0.999 5). The LOD and LOQ were 0.20 μg·L^-1 and 0.95 μg·L^-1, respectively. The characteristic concentration (sensitivity) was 0.57 μg·L^-1 and the average recovery was 101.69%. CONCLUSION This method is sensitive, accurate and reliable to control the residues of Pd in valaciclovir hydrochloride, providing the basis for drug quality control.