| 引用本文: | 陈超,俞辉.石墨炉原子吸收法测定盐酸伐昔洛韦中钯的残留量[J].中国现代应用药学,2011,28(3):260-262. |
| CHEN Chao,YU Hui.Palladium Residues Determination in Valaciclovir Hydrochloride by Graphite Furnace Atomic Absorption Spectrometry[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(3):260-262. |
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| 摘要: |
| 目的 建立盐酸伐昔洛韦中钯残留量的测定方法。方法 采用微波消解系统消解样品，石墨炉原子吸收分光光度法测定盐酸伐昔洛韦中钯的残留量。结果 钯在浓度1.0~30.0 μg·L-1内呈良好线性关系(r=0.999 5)。检出限为0.20 μg·L-1，定量限为0.95 μg·L-1，特征浓度(灵敏度)为0.57 μg·L-1，平均回收率为101.69%。结论 采用本法测定盐酸伐昔洛韦中钯的残留量灵敏、准确、可靠，为药品质量控制提供依据。 |
| 关键词: 石墨炉原子吸收分光光度法 钯 盐酸伐昔洛韦 |
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| Palladium Residues Determination in Valaciclovir Hydrochloride by Graphite Furnace Atomic Absorption Spectrometry |
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CHEN Chao, YU Hui
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Zhejiang Insititute for Food and Drug Control, Hangzhou 310004, China
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| Abstract: |
| OBJECTIVE To establish a method for the determination of Pd in valaciclovir hydrochloride. METHODS Appling microwave degrading system to deteriorate sample, use a graphite furnace atomic absorption spectrometry (AAS) method to determine Pd residues in valaciclovir hydrochloride. RESULTS It showed a good linear relationship within the concentration range of 1.0-30.0 μg·L-1(r=0.999 5). The LOD and LOQ were 0.20 μg·L-1 and 0.95 μg·L-1, respectively. The characteristic concentration (sensitivity) was 0.57 μg·L-1 and the average recovery was 101.69%. CONCLUSION This method is sensitive, accurate and reliable to control the residues of Pd in valaciclovir hydrochloride, providing the basis for drug quality control. |
| Key words: graphite furnace atomic absorption spectrometry palladium valaciclovir hydrochloride |
