| 引用本文: | 何群,滕久祥,彭芝配,赵碧清,王适,史艳霞.喷雾与减压干燥的秦香止泻干膏粉吸湿性及流动性比较[J].中国现代应用药学,2011,28(3):218-222. |
| HE Qun,TENG Jiuxiang,PENG Zhipei,ZHAO Biqing,WANG Shi,SHI Yanxia.Comparison of Spray Drying and Decompression Drying on Hydroscopicity and Fluidity of Dry Powdered Extract of Qinxiangzhixie[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(3):218-222. |
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| 摘要: |
| 目的 比较喷雾干燥法与减压干燥法对秦香止泻干浸膏粉吸湿性及流动性的影响，为确定秦香止泻浓缩液(或稠浸膏)合理的干燥方法提供依据。方法 通过测定秦香止泻干浸膏粉的吸湿速度，吸湿量达2%时的相对湿度(relative humidit，RH)，建立其动力学模型，提取吸湿速度参数并比较大小；通过测定秦香止泻干浸膏粉的休止角比较流动性优劣。结果 两种干燥方法制成的干浸膏粉吸湿动力学模型皆符合对数正态分布模型，减压干燥比喷雾干燥吸湿速度快，吸湿量随RH变化的函数关系，喷雾干燥粉符合逻辑斯蒂模型；减压干燥粉符合修正指数函数曲线，吸湿量达2%时的RH，喷雾干燥粉为90.12%；减压干燥85.81%，减压干燥法比喷雾干燥法制成的干浸膏粉休止角大，流动性差。结论 喷雾干燥制成的干浸膏粉不易吸湿，稳定性好，流动性好。 |
| 关键词: 秦香止泻干浸膏粉 喷雾干燥 减压干燥 相对湿度 吸湿速度 流动性 |
| DOI： |
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| 基金项目:湖南省教育厅重点项目(05A032) |
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| Comparison of Spray Drying and Decompression Drying on Hydroscopicity and Fluidity of Dry Powdered Extract of Qinxiangzhixie |
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HE Qun1, TENG Jiuxiang2, PENG Zhipei2, ZHAO Biqing2, WANG Shi3, SHI Yanxia3
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1.Hunan University of Traditional Chinese Medicine, College of Pharmacy, Drug Modernization Laboratory of Traditional Chinese Medicine and Drug, Changsha 410208, China;2.Hunan University of Traditional Chinese Medicine, Drug Modernization Laboratory of Traditional Chinese Medicine and Drug, Changsha 410208, China;3.Hunan University of Traditional Chinese Medicine, a.College of Pharmacy, b.Drug Modernization Laboratory of Traditional Chinese Medicine and Drug, Changsha 410208, China
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| Abstract: |
| OBJECTIVE To select a reasonable dry method for extracting dry powdered Qinxiangzhixie, meanwhile to provide basis for future research, we compared the influence of spray drying and decompression drying on hydroscopicity and fluidity of dry powdered extract of Qinxiangzhixie. METHODS The moisture absorption speed of dry powder extract of Qinxiangzhixie was determined. Its dynamics model was established, when the relative humidity (RH) of moisture absorption reached 2%. The parameter of moisture absorption speed was collected and compared. Its fluidity was contrasted through inspecting the angle of repose dry powdered Qinxiangzhixie. RESULTS Both of the dry methods dynamics model were conformed to log-normal model. However, the moisture absorption speed of decompression drying was quicker than spray drying. The research also demonstrated that the function of moisture absorption capacity-RH conformed to Logistic model, and the dry powder extract of decompression drying conformed to amended exponential function curve. When the moisture absorption amounts 2%, the relative humidity of the dry powdered extract of spray drying was 90.12%, and the dry powdered extract of decompression drying was 85.81%. That means the angle of repose of the dry powder extract of decompression drying was larger than spray drying and the fluidity of the dry powder extract of decompression drying was poorer than spray drying. CONCLUSION The dry powder extract by spray drying is less absorption, more stable and fluid. |
| Key words: Qinxiangzhixie drug extractum spray drying decompression drying relative humidit moisture absorption speed fluidity |
