| 引用本文: | 金祖汉,王香英,金捷,毛培江,杨毅.戒毒康的戒毒作用研究[J].中国现代应用药学,2011,28(4):288-290. |
| JIN Zuhan,WANG Xiangying,JIN Jie,MAO Peijiang,YANG Yi.Study on Effects of Jiedukang in Drug Addiction Treatments[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(4):288-290. |
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| 摘要: |
| 目的 研究戒毒康的戒毒作用，为戒毒康的新药开发提供实验基础。方法 利用热板镇痛试验和醋酸扭体试验观察戒毒康的镇痛作用；利用对域上剂量戊巴比妥钠麻醉协同作用观察戒毒康的催眠效果；利用吗啡成瘾小鼠模型观察戒毒康对药物依赖性戒断后的治疗作用。结果 戒毒康能减少醋酸致小鼠扭体的次数，延长小鼠舔后足的潜伏期；与戊巴比钠域上剂量的催眠作用有协同作用；抑制小鼠吗啡成瘾戒断后的跳跃，恢复戒断后的体重。结论 戒毒康有明显的镇痛、催眠和改善小鼠吗啡依赖性戒断后的症状作用，有较好的新药开发前景。 |
| 关键词: 戒毒康 镇痛作用 催眠作用 戒毒治疗 |
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| 基金项目:浙江省科技厅科研院所重点开发项目(2006F12035) |
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| Study on Effects of Jiedukang in Drug Addiction Treatments |
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JIN Zuhan1, WANG Xiangying2, JIN Jie1, MAO Peijiang1, YANG Yi1
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1.Zhejiang Research Institute of Chinese Materia Medica, Hangzhou 310023, China;2.Hospital of Zhejiang University, Hangzhou 310058, China
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| Abstract: |
| OBJECTIVE To study the effects of Jiedukang for treating drug addicts and to provide preliminary experiment basement. METHODS Hot plate inducing pain method and acetic acid writhing method were used to observe the analgesic effects. And up-limen dose of pentobarbital sodium was used to observe the hypnotic action. Morphine addicted model in mouse was used to observe the treating effects of relieve drug withdrawal symptoms. RESULTS Jiedukang could decrease the degree of body torsion caused by acetic acid and prolong foot-licking latency in hot plate test; cooperate with pentobarbital sodium’s up-limen dose hypnotic effect; restrain the jumping of morphine-withdrawal mice and regain their bodyweight. CONCLUSION Jiedukang has analgesia, hypnotic effects and can relieve mophine withdrawal symptoms. It has good prospects for new drug development. |
| Key words: Jiedukang analgesia effect hypnotic effect treating drug addicts |
