血管紧张素转换酶抑制剂不良反应回顾性分析

Literature Analysis of Adverse Drug Reaction Induced by Angiotensin Converting Enzyme Inhibitor

关键词:  血管紧张素转换酶抑制剂  不良反应  分析

Key words:  angiotensin converting enzyme inhibitor  adverse drug reaction  literature analysis

摘要:

目的 探讨血管紧张素转换酶抑制剂(ACEI)所致不良反应的临床特征及相关因素，为临床合理用药提供参考依据。方法 检索1989年1月—2010年4月国内医药期刊报道的ACEI致不良反应案例，得到符合标准的病例838例，并对其进行统计、分析。结果 ACEI所致不良反应在高龄组较多。不良反应累及机体多个系统，以呼吸系统最多(581例，占69.33%)，不良反应预后总体较好。结论 引发ACEI不良反应的原因很多，正确认识并全方位监测可有效减少甚至避免不良反应的发生。

Abstract:

OBJECTIVE To discuss the characteristics and generally clinical patterns of adverse drug reaction(ADR) induced by angiotensin converting enzyme inhibitor(ACEI). METHODS The 838 ADR cases induced by ACEI which were reported in internal medical journals published from Jan 1989 to Apr 2010 were collected by retrieving China hospital digital library and analyzed statistically. RESULTS The ADR cases induced by ACEI are much more in the elder. The ADRs involved multiple systems, expecially the respiratory system (581 cases, 69.33%). The prognosis of ADR is generally good. CONCLUSION The cause of ADR induced by ACEI is varied. Correct understanding and omnibearing monitoring can effectively reduce or even avoid the occurrence of ADR induced by ACEI.