| 引用本文: | 王溶溶,陈丹菲,汤建成,潘建明.坤怡宁颗粒的制备工艺研究[J].中国现代应用药学,2011,28(9):850-853. |
| WANG Rongrong,CHEN Danfei,TANG Jiancheng,PAN Jianming.Study on the Preparation Technology of Kunyining Granule[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(9):850-853. |
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| 摘要: |
| 目的 研究坤怡宁颗粒的制备工艺。方法 以出膏率和芍药苷总量为指标，正交试验法优选水提条件；以颗粒吸湿性、流动性和成型性为指标，筛选颗粒最佳辅料与配比。结果 最佳提取工艺为药材加10倍量水，煎煮2次，每次1.5 h；制备坤怡宁颗粒的最优处方组成为：1份浸膏与1份辅料(乳糖∶蔗糖粉∶糊精=3∶1∶1)混合制粒。结论 该制备工艺合理、简便、实用，质量稳定。 |
| 关键词: 坤怡宁颗粒 正交试验 工艺研究 |
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| Study on the Preparation Technology of Kunyining Granule |
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WANG Rongrong, CHEN Danfei, TANG Jiancheng, PAN Jianming
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Zhejiang Institute of Chinese Materia Medica, Hangzhou 310023, China
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| Abstract: |
| OBJECTIVE To optimize the preparation process of Kunyining granule. METHODS With the paste-forming rate and total content of paeoniflorin as the indexes, the optimal water-extraction condition was screened by orthogonal design. With hydroscopicity, fluidity and formability as the indexes, the appropriate ratio of the excipient and the formula were selected. RESULTS The optimum water-extraction condition was as follows: 10-fold water, decoction for 2 times and 1.5 hour for each time. The optimal ratio of the excipient and the formula for preparation of Kunyining granules were one proportions of the extract and one proportion of the excipient which consisted of lactose, sucrose powder and dextrin(3∶1∶1). CONCLUSION The technology is effective, scientific, reasonable, and practical. |
| Key words: Kunyining granule orthogonal design process research |
