| 引用本文: | 袁泽利,吴庆,胡庆红,钟永科,周旭美.含 2-取代-1,3-二硫杂环戊烷席夫碱大环化合物的合成及其抑菌活性研究[J].中国现代应用药学,2011,28(13):1331-1333. |
| YUAN Zeli,WU Qing,HU Qinghong,ZHONG Yongke,ZHOU Xumei.Synthesis and Antibacterical Activity of Novel Macrocyclic Schiff Base Compounds Containing 2-Substituted-1,3-dithiolane[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(13):1331-1333. |
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| 摘要: |
| 目的 开发新型抗菌药物。方法 以不同的β-二酮、二硫化碳、1,2-二溴乙烷等为原料合成含2-取代-1,3-二硫杂环戊烷大环席夫碱化合物，并进行初步抑菌活性研究。结果 合成得到的中间体(Ⅰa~Ⅰc)及目标席夫碱大环化合物(Ⅱa~Ⅱc)经元素分析、红外光谱、1H-NMR、MS等手段进行了结构表征。合成的席夫碱大环化合物抑菌能力优越。结论 本试验合成了含2-取代-1,3-二硫杂环戊烷大环席夫碱化合物，其具有更加优越的抑菌能力。 |
| 关键词: 2-取代-1,3-二硫杂环戊烷 席夫碱 合成 抑菌活性 |
| DOI： |
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| 基金项目:贵州省科学技术基金(黔科合J字[2010]2223) |
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| Synthesis and Antibacterical Activity of Novel Macrocyclic Schiff Base Compounds Containing 2-Substituted-1,3-dithiolane |
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YUAN Zeli, WU Qing, HU Qinghong, ZHONG Yongke, ZHOU Xumei
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School of Pharmacy, Zunyi Medical College, Zunyi 563003, China
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| Abstract: |
| OBJECTIVE To exploit a novel antibacterical agent. METHODS A series of macrocyclic Schiff base compounds containing 2-substituted-1,3-dithiolane were synthesized from different β-diketonato, carbon disolfide and 1,2-dibromoethane. Their antibacterial activities were tested. RESULTS The structure and composition of the middle compounds(Ⅰa-Ⅰc) and title Schiff base compounds(Ⅱa-Ⅱc) were elucidated on the basis of elemental analysis, IR, 1H-NMR, and MS. The title Schiff base compounds proved a better antibacterial activity. CONCLUSION The title Schiff base compounds(Ⅱa-Ⅱc) are synthesized, and they show good antibacterial activity. |
| Key words: 2-substituted-1,3-dithiolane Schiff base synthesis antibacterial activity |
