| 引用本文: | 刘旭，温新国，缪旭，陈宝，陆明，吴传斌.固体分散体物理稳定性影响因素及抗老化研究进展[J].中国现代应用药学,2011,28(8):710-717. |
| LIU Xu, WENG Xinguo, MIAO Xu, CHEN Bao, LU Ming, WU Chuanbin.Progress in the Study on Physical Stability and Anti-aging of Soild Dispersion[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(8):710-717. |
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| 摘要: |
| 目的 综述固体分散体的物理稳定性影响因素及抗老化研究进展。方法 分析、整理和归纳近几年相关文献。结果 本文从物理化学角度出发，将影响固体分散体稳定性的因素分为热力学和动力学两个方面，对其研究进展进行了综述，并就处方设计、制备工艺和贮存条件等方面，提出了抗老化的几点方法和建议。结论 固体分散体物理稳定性机制的深入研究，将促进固体分散技术的进一步发展。 |
| 关键词: 固体分散体 物理稳定性 抗老化 |
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| 基金项目:广东省高校创新药物制剂工程技术研究中心资助项目(GCZX-A0801) |
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| Progress in the Study on Physical Stability and Anti-aging of Soild Dispersion |
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LIU Xu, WENG Xinguo, MIAO Xu, CHEN Bao, LU Ming, WU Chuanbin1,2
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1.School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;2.Guangdong Research Center for Drug Delivery Systems, Guangzhou 510006, China
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| Abstract: |
| OBJECTIVE To summary of progress in the study on physical stability and anti-aging of soild dispersion. METHODS The relevant articles in recent years were referred and summarized. RESULTS Thermodynamic and kinetic factors for the physical stability of solid dispersion were reviewed. Suggestions about the formulation design, preparation method and storage conditions to improve the physical stability of solid dispersion were also introduced. CONCLUSION The intensive study of physical stability mechanism of soild dispersion will promote the development of this technology in pharmaceutical research. |
| Key words: solid dispersion physical stability anti-aging |
