氯沙坦钾片对原发性高血压合并2型糖尿病患者血压变异性和肱踝脉搏波传导速度的影响

Effect of Losartan on Blood Pressure Variability and Brachial-ankle Pulse Wave Velocity in Essential Hypertensive Patients Complicated with Type 2 Diabetes Mellitus

关键词:  氯沙坦钾片  原发性高血压  2型糖尿病  血压变异性  肱踝脉搏波传导速度

Key words:  losartan potassium tablets  essential hypertension  type 2 diabetes mellitus  blood pressure variability  brachial-ankle pulse wave velocity

摘要:

目的 探讨原发性高血压合并2型糖尿病患者血压变异性(BPV)和肱踝脉搏波传导速度(baPWV)的特点及科素亚对其影响。方法 60例原发性高血压合并2型糖尿病患者设为治疗组，口服氯沙坦钾片(100~200 mg·d^-1)24周，观察治疗前后BPV、baPWV的变化，并与正常对照组(58例)比较。结果 原发性高血压合并2型糖尿病患者和正常对照组比较BPV(24 h、日间、夜间、SBP和DBP的血压变异性)明显增大，baPWV明显增快。口服氯沙坦钾片(100~200 mg·d^-1)24周治疗后24 h、日间、夜间、SBP和DBP的血压变异性与治疗前比较均有统计学差异，治疗后血压变异性明显减小(P<0.01)，baPWV明显降低(P<0.01)。结论 氯沙坦钾片能降低血压和改善原发性高血压合并2型糖尿病患者血压变异性，同时还有改善患者血管弹性的作用。

Abstract:

OBJECTIVE To investigate the effect of losartan on blood pressure variability(BPV) and brachial-ankle pulse wave velocity (baPWV) in essential hypertensive (EH) patients complicated with type 2 diabetes mellitus (DM). METHODS Sixty patients with EH and DM took losartan (100-200 mg·d^-1) orally for 24 weeks(treatment group). The changes of BPV and baPWV were analyzed and compared with that of normal control group (n=58). RESULTS The BPV and baPWV of patients with EH and DM in treatment group were significantly higher than that of normal control group. After losartan treatment(24 weeks), the BPV and baPWV were significantly lower than that of the normal control group. CONCLUSION Losartan can decrease blood pressure and improve BPV, and better blood vessel stiffness.