| 引用本文: | 王正林,应俊,林圣超,姚振宇,邓卫平,杜文婷.阿托伐他汀钙的合成研究进展[J].中国现代应用药学,2011,28(5):423-428. |
| WANG Zhenglin,YING Jun,LIN Shengchao,YAO Zhenyu,DENG Weiping,DU Wenting.Progress in Synthesis of Atorvastatin Calcium[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(5):423-428. |
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| 摘要: |
| 目的 介绍了阿托伐他汀钙的研究背景，作用机制以及合成的研究进展。方法 综合国内外报道的文献，阐述阿托伐他汀钙的合成方法。结果 重点列出了3条阿托伐他汀钙的合成路线，重点分析了Paal-Knorr合成法。结论 Paal-Knorr合成法中，2种重要中间体的各种合成路线为阿托伐他汀钙的高效合成提供了新的思路。 |
| 关键词: 阿托伐他汀钙 立普妥 不对称合成 Paal-Knorr合成法 |
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| Progress in Synthesis of Atorvastatin Calcium |
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WANG Zhenglin,YING Jun,LIN Shengchao,YAO Zhenyu,DENG Weiping,DU Wenting
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| Abstract: |
| OBJECTIVE To introduce the background of atorvastatin calcium, action mechanism and the current synthetic progress. METHODS To review both domestic and international published reports regarding the synthesis of atorvastatin calcium. RESULTS To make a list of three synthetic routes of atorvastatin calcium with the emphasis on describing and analyzing the practically important synthetic method-Paal-Knorr synthesis method. CONCLUSION The development of the synthetic methods for two important intermediates provides us new ways and strategies for efficient synthesis atorvastatin calcium. |
| Key words: atorvastatin calcium lipitor asymmetric synthesis Paal-Knorr synthesis method |
