虎杖口服液对慢性阻塞性肺疾病伴肺动脉高压的临床疗效研究

Clinical Effectiveness of Poligonum Cuspidatum in COPD with Pulmonary Hypertension

关键词:  虎杖  慢性阻塞性肺疾病  肺动脉高压  血栓素B₂  6-酮-前列腺素F_1α

Key words:  Poligonum cuspidatum  chronic obstructive pulmonary disease  pulmonary hypertension  TXB₂  6-Keto-PGF_1α

摘要:

目的 探讨虎杖对慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)伴肺动脉高压患者的血流动力学及血栓素B₂、6-酮-前列腺素F_1α的影响，明确虎杖口服液的临床疗效。方法 在我院住院病人中选取COPD伴肺动脉高压的急性期患者60例，随机分为对照组(32例)和虎杖组(28例)。对照组给予常规吸氧、抗感染、化痰、平喘等治疗共21 d，虎杖组在常规治疗基础上给予虎杖口服液每次l袋，每日2次，共用药21 d，各组治疗前后分别测定心率、体循环平均压、肺动脉压、血栓素B₂、6-酮-前列腺素F_1α。结果 治疗后对照组的心率有显著改善(P<0.01)，体循环平均压、肺动脉压、血栓素B₂、6-酮-前列腺素F_1α无明显改变；虎杖组的心率有显著改善(P<0.01)，且较对照组无明显差异(P>0.05)，体循环平均压无明显改善，肺动脉压有显著改善(P<0.05)，血栓素B₂显著下降(P<0.05)，6-酮-前列腺素F_1α增高(P<0.05)。结论 虎杖口服液能降低COPD伴肺动脉高压患者的肺动脉压力，并能减少血栓素B₂的产生，从而抑制血小板聚集和血栓形成。

Abstract:

OBJECTIVE To investigate the effect of Poligonum cuspidatum on hemodynamics and TXB₂, 6-Keto-PGF_1α in chronic obstructive pulmonary disease(COPD) with pulmonary hypertension. METHODS Sixty acute exacerbation of COPD patients with pulmonary hypertension were randomized into two groups: control group(32 patients) and Huzhang group (28 patients). The control group received ordinary therapy, and Huzhang group received extra Poligonum cuspidatum. The pulmonary artery pressure, heart rate, mean systemic artery pressure, TXB₂, and 6-Keto-PGF_1α were measured before and after treatment. RESULTS In control group, there was no significant decrease of pulmonary and systemic artery pressure, and no significant changes(P>0.05) were found in TXB₂ and 6-Keto-PGF_1α, but the heart rate was decreased(P<0.01). In Huzhang group, pulmonary artery pressure was significantly decreased(P<0.05), but the heart rate was similar to control group(P>0.05), and the mean systemic artery pressure had no changes(P>0.05). The levels of TXB₂ were decreased(P<0.05) but of 6-Keto-PGF_1α were increased(P<0.05). CONCLUSION The results suggest that Poligonum cuspidatum can significantly decline pulmonary artery of COPD with pulmonary hypertension and TXB₂.