奥氮平对首发精神分裂症患者心电图的影响

Electrocardiogram Abnormality of Olanzapine in the Treatment of First-Episode Schizophrenic Patients

关键词:  奥氮平  精神分裂症  心电图

Key words:  olanzapine  schizophrenia  electrocardiogram

摘要:

目的 探讨奥氮平对首发精神分裂症患者心电图的影响，并比较国产与进口奥氮平对心电图影响的差异。方法 选取70例首发精神分裂症患者，随机分为国产奥氮平组，进口奥氮平组，各35例，分别于治疗前及治疗后第2，4，6，8周末进行心电图检查，统计异常心电图的数目和相关信息。结果 治疗第2周时，心电图异常数国产奥氮平组较进口奥氮平组为多，有统计学差异(P<0.05)。国产奥氮平组引起窦性心动过速的人数较进口奥氮平组为多，有统计学差异(P<0.05)，其余各方面两组无统计学差异。结论 不同厂家的奥氮平治疗首发精神分裂症患者的心电图异常有差异，需要加以关注。

Abstract:

OBJECTIVE To explore the analysis of olanzapine in the treatment of first-episode schizophrenic patients. To observe the electrocardiogram changes of the patients treated with olanzapine from different manufactories. METHODS Seventy patients with first-episode schizophrenia were randomly divided into homemade olanzapine group(35 cases) and imported olanzapine group (35 cases) who were treated for 8 weeks. Statistcs to the amount and information of electrocardiogram abnormality. RESULTS At the second week, there were significant difference in electrocardiogram abnormality between homemade olanzapine group and imported olanzapine group (P<0.05). Homemade olanzapine can cause more sinus tachycardia than imported olanzapine easily(P<0.05), no difference in the other electrocardiogram abnormality between two groups. CONCLUSION There are significant difference in electrocardiogram abnormality of the two drugs from different manufactories. We should pay more attention to it.