| 摘要: |
| 美索巴莫，为一种新型中枢性肌肉松弛药物，主要作用部位在脊髓前角运动神经元，机制为抑制脊髓的多突触反射，临床上用于治疗关节肌肉扭伤、腰肌劳损、坐骨神经痛等症，也可用于增生性脊柱炎、风湿性关节炎、类风湿性关节炎的治疗，也可用于美容手术术后对疼痛的控制、严重的神经障碍和骨骼肌痉挛患者。美索巴莫是促进骨骼肌疼痛患者恢复的一种很好的辅助药物，现对其药动学、合成工艺、药理作用、临床应用及安全性等做一综述。 |
| 关键词: 肌肉松弛药 美索巴莫 安全性 |
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| Advance in Research of Methocarbamol |
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GUO Xiangfei, NI Jiaxiang
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Department of Pain Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
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| Abstract: |
| Methocarbamol is classified as a centrally acting muscle relaxant. Pharmacological studies demonstrated its main locus of action to be at the internuncial neurons of the spinal cord. It is used to treat articular muscle sprain, lumbar muscle spain and Sciatica, etc. It is also used for the treatment of hypertrophic spondylitis and rheumatoid arthritis. It can also be used for cosmetic surgery to control postoperative pain, severe muscle spasm and neurological disorders. Methocarbamol is a useful adjunct in improving patient recovery. In this article, we summarized its pharmacokinetics, synthesis, pharmacological effect, clinical use and safety. |
| Key words: muscle relaxant methocarbamol safety |
