| 引用本文: | 李鹏,魏晓霞,许建华.灵芝提取物抗肿瘤作用的实验研究[J].中国现代应用药学,2011,28(9):789-792. |
| LI Peng,WEI Xiaoxia,XU Jianhua.Experimental Study on Anti-tumor Effects of Extracts from Ganoderma Lucidum[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(9):789-792. |
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| 摘要: |
| 目的 探讨一种灵芝提取物体内外抗肿瘤作用。方法 应用小鼠H22肝癌移植瘤模型，研究灵芝提取物的体内抗肿瘤作用；采用MTT法检测灵芝提取物的体外抗肿瘤活性。结果 ①灵芝提取物对H22移植瘤呈剂量依赖性抑制作用，500 mg·kg-1组的瘤重抑制百分率达59.3%，与阴性对照组比较有统计学差异(P<0.01)；②MTT法检测显示灵芝提取物对K562和HL60两种瘤株有较强抑制作用，对SMMC7221、HepG2、SW480、SW1116和SGC7901五种瘤株抑制作用较弱。结论 灵芝提取物在体外及体内均有较强的抗肿瘤作用，其有效成分及机制有待进一步研究。 |
| 关键词: 灵芝 抗肿瘤 H22 抗癌 |
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| 基金项目:福建医科大学苗圃科研基金项目(2010MP044) |
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| Experimental Study on Anti-tumor Effects of Extracts from Ganoderma Lucidum |
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LI Peng1, WEI Xiaoxia2, XU Jianhua3
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1.Fujian Medical University, School of Pharmacy, a. Department of Natural Medicines, Fuzhou 350004, China;2.Fujian Medical University, School of Pharmacy, b. Department of Pharmacology, Fuzhou 350004, China;3.Fujian Medical University, School of Pharmacy, b. Department of Pharmacology, Fuzhou 350004, China
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| Abstract: |
| OBJECTIVE To explore anti-tumor effects of extracts from Ganoderma Lucidum(GLE). METHODS Anticancer effects of GLE were experimented by mice bearing H22 hepatocarcinoma transplantation tumor model in vivo and MTT reduction test in vitro. RESULTS ①GLE could inhibit H22 transplanted tumor growth in mice in a dose-dependent manner, the inhibitive percentage of carcinoma weight was 59.3% in 500 mg·kg-1 group and there was obviously differentiation when comparing with negative control group(P<0.01). ②GLE had an inhibitory effect on the proliferation of K562 and HL60 human tumor cells and had less inhibitory activity on SMMC7221, HepG2, SW480, SW1116 and SGC7901 human tumor cells. CONCLUSION This study confirms that GLE has significant anticancer effect in vitro and vivo. However, the mechanism and active ingredients remain to be studied. |
| Key words: Ganoderma Lucidum anticancer H22 anti-tumor |
