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| 摘要: |
| 报道了以邻氯硝基苯为原料合成可乐定(1)的新方法。邻氯硝基苯先经锌粉、氯化铵还原和甲酸、乙酐甲酰化得N-(2-氯苯基)-N-羟基甲酰胺(3),再经氯化亚砜、五氯化磷氯化,然后与己二胺环合得(1).此法操作简便,成本较低,总收率21.8%。 |
| 关键词: 可乐定 氯化 环合 合成 |
| DOI： |
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| A new Synthetic Method of Clonidine |
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Yang Yiuhong; Yang Jia-she
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| Abstract: |
| A new synthetic method of clonidine (I) is reported from o-chloronitrobenzeneas the starting material .N-(2-chloro-phenyl)-N-hydroxyformamide is prepared from o-chl-oronitrobenzene as reduction with formic acid/acetic anhydride . is converted to clonidine |
| Key words: clonidine chlorination cyclization synthesis |
