| 引用本文: | 傅旭春;李光华.6,8-二氟喹诺酮类抗菌药物的构效关系研究[J].中国现代应用药学,1997,(1):31-33. |
| Fu Xu-chun ;Li Guang-hua.Study on the Structure-activity Relationships of 6, 8-difluoroquinolone Antibacterials[J].Chin J Mod Appl Pharm(中国现代应用药学),1997,(1):31-33. |
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| 摘要: |
| 研究了10个6,8-二氟喹诺酮类抗菌药在N1和C7位取代基的结构与抗菌活性的关系。结果表明,N1取代基除了必须符合适当的STERIMOL长度外,还要有一定的脂溶性;C7位取代基主要是脂溶性因素影响化合物的抗菌活性。 |
| 关键词: 6,8-二氟喹诺酮 抗菌药 构效关系 |
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| Study on the Structure-activity Relationships of 6, 8-difluoroquinolone Antibacterials |
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Fu Xu-chun ;Li Guang-hua
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| Abstract: |
| The structure-activity relationships of ten 6, 8-difluoroquinolones, have been studidd.The results showed that the N1-substitutent,should be lipophilic in addition to adapt theoptimal STERIMOL length. C7-substitutent affected the antibacterial activity of |
| Key words: 6, 8-difluoroquinolone Antibacterials structure-activity relationships |
