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| 摘要: |
| 考察了溶液PH对有机弱酸类药物吡罗昔康和双氟芬酸钠的离子导入透皮(大鼠腹部皮)速率的影响,当溶液PH>5时,溶液pH值与吡罗昔康和双氯芬酸钠离子导入透皮速率有线性关系,但当溶液pH<5时,此线性关系不再成立,认为可能由于电渗作用方向的改变所引起。 |
| 关键词: 离子导入 pH值 吡罗昔康 双氯芬酸钠 |
| DOI： |
| 分类号: |
| 基金项目:国家自然科学基金 |
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| The Influence of pH on the Mechanism of Percutaneous Iontophoresis of Piroxicam and Diclofenac Sodium |
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Gao Jian-qing; Liang Wen-quan
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| Abstract: |
| We Studied the influence of PH values on non-steroid anti-inflammatory drugs such as piroxicam, diclofenac sodium iontophorctic transdermal through rat abdomal skin in vitro. The results showed that when PH>5, the linear relationship existed between PH va |
| Key words: iontophoresls pH values piroxicam diclofenac sodium |
