| 引用本文: | 蔡小淦;姚彤炜1;潘莉1;宗俭1.β-环糊精流动相和手性配位交换HPLC法分离药物对映体[J].中国现代应用药学,1998,(5):36-38. |
| Cai Xiaogan(Cai XG),Yao Tongwei(Yao TW),Pan Li (Pan L),et al.Separation of drug enantiomers by HPLC with chiral mobile phase additive[J].Chin J Mod Appl Pharm(中国现代应用药学),1998,(5):36-38. |
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| 摘要: |
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| 关键词: 药物对映体分离 手性流动相添加剂 β-环糊精 手性配位交换 |
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| 基金项目:国家自然科学基金(39370805);;浙江省自然科学基金(393031)资助项目 |
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| Separation of drug enantiomers by HPLC with chiral mobile phase additive |
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Cai Xiaogan(Cai XG),Yao Tongwei(Yao TW),Pan Li (Pan L),et al
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| Abstract: |
| OBJECTIVE: Develop a chiral mobile phase additive HPLC method to separate and determine drug enantiomers in biological sample. METHODS: p - HPPH, Mephenytoin, Terbutaline, Chlorthalidone and Ofloxacin in biological sample were separated and determined usi |
| Key words: separation of drug enantiomers,β-cyclodextrin,chiral ligand - exchange,chiral mobile phase additive |
