| 引用本文: | 单世明;安鲁凡;余书勤;徐为人1;梁田1.抗溃疡药瑞巴匹特的合成[J].中国现代应用药学,2000,(4):296-297. |
| Shan Shiming(Shan SM),An Lufan(An LF),Yu Shuqin(Yu SQ),et al.Synthesis of ribamipide an antiulcer agent[J].Chin J Mod Appl Pharm(中国现代应用药学),2000,(4):296-297. |
|
|
| 摘要: |
| 目的:合成抗溃疡药2-( 4-氯苯甲酰胺基)-3-( 1 ,2-二氢2-氧代 4-喹啉基)丙酸(瑞巴匹特)。方法:以乙酰乙酰苯胺为起始原料,经溴化,成环,取代,酸解,及缩合等五步反应合成该化合物。结果:合成产物经元素分析,红外光谱,核磁共振谱,质谱等确证。结论:此合成路线是完全可行的。 |
| 关键词: 瑞巴匹特 抗溃疡药 合成 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Synthesis of ribamipide an antiulcer agent |
|
Shan Shiming(Shan SM),An Lufan(An LF),Yu Shuqin(Yu SQ),et al
|
| Abstract: |
| OBJECTIVE:To synthesize 2-(4-Chlorobenzoylamino)-3-(1,2-dihydro-2-oxo-4-quinolyl) propionic acid(ribamipide).METHOD:With acetoactanilide as the starting material,ribamipide was synthesized by bromination,cycloration,substitution,acidification,and condensa |
| Key words: ribamipide,antiulcer agent,synthesis |
