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| 摘要: |
| 目的:研究大剂量顺铂化疗的药动学。方法:用HPLC法测定血浆顺铂浓度。结果:血浆顺铂的药代动力学模式为开放二室模型,t1/2α为18.6 0 6min ,t1/2β为4 1.1782h。结论:大剂量顺铂化疗的t1/2β达4 1.1782h ,给药间隔须在三周以上 |
| 关键词: 高效液相色谱 顺铂 药代动力学 |
| DOI： |
| 分类号: |
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| Pharmacokinetic Study of High Dose Cis-platin Chemotherapy |
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Weng lin, Chen Lingya
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| Abstract: |
| OBJECTIVE:Studied the pharmacokinetics of High Dose Cis-platin Chemotherapy. METHOD:The Platinum concentration was measured by HPLC.RESULTS:The results showed that the plasma clearance of platinum was biphasic. There was a short initial phase with a half |
| Key words: HPLC, DDP, pharmacokinetics |
