| 引用本文: | 薛洪源;侯艳宁;刘会臣.异烟肼与利福平合用致肝毒性增加机制的研究概况[J].中国现代应用药学,2002,(6):463-465. |
| Xue Hongyuan, Hou Yanning, Liu Huichen.The general investigation of the increased hepatotoxicity caused by isoniazid in combination with rifampin[J].Chin J Mod Appl Pharm(中国现代应用药学),2002,(6):463-465. |
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| 摘要: |
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| 关键词: 异烟肼 利福平 联合用药 肝毒性 细胞色素P450酶 肝药酶 |
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| The general investigation of the increased hepatotoxicity caused by isoniazid in combination with rifampin |
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Xue Hongyuan, Hou Yanning, Liu Huichen
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| Abstract: |
| OBJECTIVE:To summarize the investigations of the increased hepatotoxicity caused by the combined action of isoniazid (INH) and rifampicin (RFP) . METHOD:To consult recent years' papers, summarize the mechanisms of the metabolism of INH, and analyse the i |
| Key words: isoniazid, rifampicin, drug interactions, hepatic enzymes , microsomal cytochrome P450, hepatotoxicity |
