| 引用本文: | 金庆平,赖月琴.神经内肽酶抑制剂消旋卡多曲(Racecadotril)的合成工艺研究[J].中国现代应用药学,2003,(7):25-27. |
| JIN Qing-ping,LAI Yue-qin.Synthesis of antisecretory enkephalinase inhibitor racecadotril[J].Chin J Mod Appl Pharm(中国现代应用药学),2003,(7):25-27. |
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| 摘要: |
| 目的合成神经内肽酶抑制剂消旋卡多曲。
方法以氯苄为起始原料，经六步反应合成消旋卡多曲。结果每步反应均经改进，总收率为60%。所得产品经元素分析，IR,1HNMR,13CNMR光谱数据与文献报
道一致。结论本工艺路线方法简单，原料易得，适合工业化生产。 |
| 关键词: 消旋卡多曲 合成 抗分泌神经内肽酶抑制剂 |
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| Synthesis of antisecretory enkephalinase inhibitor racecadotril |
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JIN Qing-ping,LAI Yue-qin
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| Abstract: |
| OBJECTIVETo synthesize Racecadotril , a new drug for antisecretory enkephalinase inhibitor. METHODWith
the benzyl chloride as the starting material, Racecadotril was synthesized via a six-step.RESULTSEach step was modified and improved ,the total yield w |
| Key words: racecadotril acetorphan enkephalinase inhibitor synthesis |
