| 引用本文: | 徐翔1;田国祥1;许东航1;叶婷2;梁文权2.不同pH的溶出介质对HPMC骨架片释药的影响[J].中国现代应用药学,2004,(2):108-110. |
| XU Xiang 1, TIAN Guo-xiang 1, XU Dong-hang 1, YE Ting 2, LIANG Wen-quan 2.Influence of media with different pH on drug release from HPMC hydrogel matrix[J].Chin J Mod Appl Pharm(中国现代应用药学),2004,(2):108-110. |
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| 摘要: |
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| 关键词: 难溶性药物 HPMC骨架片 pH 溶解度 释放度 |
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| 基金项目:浙江省自然科学基金 (399111)资助 |
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| Influence of media with different pH on drug release from HPMC hydrogel matrix |
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XU Xiang 1, TIAN Guo-xiang 1, XU Dong-hang 1, YE Ting 2, LIANG Wen-quan 2
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| Abstract: |
| OBJECTIVE To study the effect of pH on insoluble drug release from HPMC hydrogel matrix. METHOD Trimethoprim,carbamazepine,sulfamethoxazole and theophylline were employed as model drugs,the rates of drugs release and their solubility were determined res |
| Key words: insoluble drug HPMC matrix tablet pH solubility dissolution |
