| 引用本文: | 郭春1;方林1;Xiaohui Du2;E.Cohen2.N,N-双取代脲类克鲁斯氏锥体虫半胱氨酸蛋白酶小分子抑制剂的合成及其活性研究[J].中国现代应用药学,2004,(5):361-365. |
| GUO Chun,FANG Lin,Xiaohui Du,Fred E.Cohen.Study on the synthesis and bioactivity of N,N-bis-substituted urea derivatives as novel small molecular inhibitors of cysteine protease of Tryponosoma cruzi[J].Chin J Mod Appl Pharm(中国现代应用药学),2004,(5):361-365. |
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| 摘要: |
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| 关键词: 克鲁斯氏锥体虫体半胱氨酸蛋白酶 抑制剂 N,N-双取代脲 合成 |
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| Study on the synthesis and bioactivity of N,N-bis-substituted urea derivatives as novel small molecular inhibitors of cysteine protease of Tryponosoma cruzi |
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GUO Chun,FANG Lin,Xiaohui Du,Fred E.Cohen
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| Abstract: |
| OBJECTIVE To search the small molecular inhibitors of cysteine protease of Tryponosoma cruzi.METHOD The N,N-bis-substituted urea was chosen as the lead scaffold based on the computational molecular modeling of cruzain. The target compounds were synthesi |
| Key words: cysteine protease of Tryponosoma cruzi inhibitor ,-bis-substituted urea synthesis |
