| 引用本文: | 柴雨柱;徐军;严相平;杜云;王浦海;冷宗康.Ⅲ类抗心律失常药多非利特的合成[J].中国现代应用药学,2004,(5):377-378. |
| CHAI Yu-zhu, XU Jun, YAN Xiang-ping,DU Yun,WANG Pu-hai, LENG Zong-kang.Synthesis of class Ⅲ antiarrhythmic agent Dofetilide[J].Chin J Mod Appl Pharm(中国现代应用药学),2004,(5):377-378. |
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| 关键词: 抗心律失常药 多非利特 合成 |
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| Synthesis of class Ⅲ antiarrhythmic agent Dofetilide |
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CHAI Yu-zhu, XU Jun, YAN Xiang-ping,DU Yun,WANG Pu-hai, LENG Zong-kang
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| Abstract: |
| OBJECTIVE To synthesize dofetilide and optimize the process. METHOD Dofetilide was synthesized by steps of reaction (substitution ,reduction, methylsulfonylation and methylammoniation, etc) from p-nitrophenol and p-amino phenethyl alcohol. RESULTS Chem |
| Key words: class Ⅲ antiarrhythmic agent Dofetilide synthesis |
