| 引用本文: | 茅海琼1,2;曾苏1.大鼠肝微粒体中美西律对映体氧化代谢的立体选择性研究[J].中国现代应用药学,2005,(5):360-363. |
| MAO Hai-qiong~(1,2),ZENG Su~1.Study on the stereoselectivity of oxidation metabolism of mexiletine enantiomers in rat liver microsome[J].Chin J Mod Appl Pharm(中国现代应用药学),2005,(5):360-363. |
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| 摘要: |
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| 关键词: 美西律 对映体 肝微粒体 立体选择性 氧化代谢 |
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| 基金项目:国家自然科学基金(30225047)资助 |
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| Study on the stereoselectivity of oxidation metabolism of mexiletine enantiomers in rat liver microsome |
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MAO Hai-qiong~(1,2),ZENG Su~1
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| Abstract: |
| OBJECTIVE To Study the stereoselectivity of oxidation metabolism of mexiletine enantiomers in rat liver microsome.METHODS The time course and the parameters of enzymatic kinetics of mexiletine enantiomers,Vm and Km,were determined by a capillary gas chrom |
| Key words: mexiletine enantiomer liver microsome stereoselectivity oxidation metabolism |
