| 引用本文: | 南鹏娟;孙晓莉;王平安;王巧峰;姜茹.用两种不对称催化反应合成紫杉醇C13侧链[J].中国现代应用药学,2006,(2):114-116. |
| NAN Peng-juan,SUN Xiao-li,WANG Ping-an,WANG Qiao-feng,JIANG Ru.Synthesis of taxol C13 side chain using two catalyzed asymmetic reaction[J].Chin J Mod Appl Pharm(中国现代应用药学),2006,(2):114-116. |
|
|
| 摘要: |
|
| 关键词: 可回收配体 紫杉醇C13侧链 不对称氨羟化反应 不对称二羟化反应 |
| DOI： |
| 分类号: |
| 基金项目:国家自然科学基金课题(5037208320302014)资助 |
|
| Synthesis of taxol C13 side chain using two catalyzed asymmetic reaction |
|
NAN Peng-juan,SUN Xiao-li,WANG Ping-an,WANG Qiao-feng,JIANG Ru
|
| Abstract: |
| OBJECTIVE To develop a simple and economical method to achieve taxol side chain,(2R,3S)-isoproplyl-3-benzamido-2-hydroxy-3-phenylpropionate.METHODS The taxol C13 side chain with high ees could be prepared from asymmetric aminohydroxylation(AA) and dihydro |
| Key words: recoverable ligand taxol C13 side chain asymmetric aminohydroxylation asymmetric dihydroxylation |
