| 引用本文: | 杨宏图1;常翠1;宁德俄1;毕殿洲2.平痛新控释微丸的包衣液处方筛选[J].中国现代应用药学,2006,(2):129-131. |
| YANG Hong-tu1,CHANG Cui1,NING De-e1,BI Dian-zhou2.Select the coating fluid prescription of nefopam controlled release pellets[J].Chin J Mod Appl Pharm(中国现代应用药学),2006,(2):129-131. |
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| 摘要: |
| 目的筛选平痛新控释微丸包衣液处方。方法用单因素实验方法考察了包衣液中溶媒系统的组成、膜材的浓度、致孔剂和增塑剂对药物释放的影响。结果膜材浓度增加、水比例增大释药速度加快;加入PVPK30,加快释药,这些与包衣厚度共同决定衣膜的控释能力。结论包衣液处方合理、实用。 |
| 关键词: 平痛新 控释微丸 包衣液 |
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| Select the coating fluid prescription of nefopam controlled release pellets |
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YANG Hong-tu1,CHANG Cui1,NING De-e1,BI Dian-zhou2
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| Abstract: |
| OBJECTIVE To select the coating fluid prescription of nefopam controlled release pellets.METHODS Sigle-factor method was used to investigate the several factors affecting the drug release rate in coating solution. RESULTS When the concentration of coating |
| Key words: nefopam controlled release pellets coating fluid |
