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| 摘要: |
| 目的合成溴匹立明并进行工艺改进。方法以乙酰乙酸乙酯为起始原料,经酰化、环合、溴化3步反应合成溴匹立明。结果所得产物化学结构经红外光谱、核磁共振氢谱及质谱确证,总收率为44.2%。结论改进的合成工艺简便、合理且可行。 |
| 关键词: 溴匹立明 膀胱癌 合成 |
| DOI： |
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| 基金项目: |
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| Improve on the synthetic process of bropirimine |
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ZHANG Wan-jin
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| Abstract: |
| OBJECTIVE To synthesize bropirimine by improved method. METHODS Bropirimine was synthesized by 3 steps reaction of acylation, cyclization and bromination with ethyl acetoacetate as staring material. RESULTS Chemical structure of the product was confirmed |
| Key words: bropirimne bladder cancer synthesis |
