| 引用本文: | 王尊元;梁美好;马臻;沈正荣.(S)-(+)-氟比洛芬的合成[J].中国现代应用药学,2006,(6):463-465. |
| WANG Zun-yuan,LIANG Mei-hao,MA Zhen,SHEN Zheng-rong.New preparation of(S)-(+)-flurbiprofen[J].Chin J Mod Appl Pharm(中国现代应用药学),2006,(6):463-465. |
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| 摘要: |
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| 关键词: 氟比洛芬 合成 拆分 |
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| New preparation of(S)-(+)-flurbiprofen |
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WANG Zun-yuan,LIANG Mei-hao,MA Zhen,SHEN Zheng-rong
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| Abstract: |
| OBJECTIVE To synthesize S-enantiomer of non-steroids anti-inflammation drug flurbiporfen.METHODS 2-Fluoroaniline was brominated with 1,3-dibromo-5,5-dimethylhydantoin,then condensed with benzene to give 2-fluoro-4-bromo-biphenyl,which reacted with sodium |
| Key words: S-flurbiprofen synthesis resolution |
