| 引用本文: | 姚琰1;何文1;张冕2;王军1.N-三甲基壳聚糖对环孢素经皮渗透作用的试验研究[J].中国现代应用药学,2006,(9):901-903. |
| YAO Yan~(1),HE Wen~(1),ZHANG Mian~(2),WANG Jun~(1).Study on the penetration effect of N-trimethyl chitosan on Cyclosporin[J].Chin J Mod Appl Pharm(中国现代应用药学),2006,(9):901-903. |
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| 关键词: N-三甲基壳聚糖 透皮吸收促进作用 累积透过量 稳态透皮速率 |
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| Study on the penetration effect of N-trimethyl chitosan on Cyclosporin |
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YAO Yan~(1),HE Wen~(1),ZHANG Mian~(2),WANG Jun~(1)
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| Abstract: |
| OBJECTIVE To study the penetration effect of N-trimethyl chitosan(TMC) on Cyclosporin.METHODS TMC60 was synthesized by a two-step method using chitosan and methyl-iodide.The degree of quaternization(DQ) of TMC was determined by 1H-NMR.The excised mice ski |
| Key words: N-trimethyl chitosan Penetration enhancement Cumulative penetration Steady penetration rate |
