| 引用本文: | 张来国1,2;罗世能1,2;谢敏浩1;刘晓亚2.N,N'-双(1-羟基甲基-2,3-二羟基丙基)-2,3,5,6-四碘对苯二甲酰胺的合成[J].中国现代应用药学,2007,(2):126-127. |
| ZHANG Lai-guo1,2,LUO Shi-neng1,2,XIE Min-hao1,LIU Xiao-ya2.Synthesis of N,N'-bis(1-hydroxymethyl-2,3-dihydroxypropxyl)-2,3,5,6-Tetraiodo-terephthalamide[J].Chin J Mod Appl Pharm(中国现代应用药学),2007,(2):126-127. |
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| 摘要: |
| 目的设计并合成标题化合物。方法以1,4-丁烯二醇为原料,经过酯化、环氧化、氨解开环,再与四碘对苯二甲酰氯反应合成目标产物。结果产物经红外、核磁共振氢谱、元素分析得到确认。结论成功的合成了所设计的标题化合物,有助于新一代四碘苯类非离子型X线造影剂的研制。 |
| 关键词: 非离子型x射线造影剂 环氧化反应 合成 |
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| Synthesis of N,N'-bis(1-hydroxymethyl-2,3-dihydroxypropxyl)-2,3,5,6-Tetraiodo-terephthalamide |
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ZHANG Lai-guo1,2,LUO Shi-neng1,2,XIE Min-hao1,LIU Xiao-ya2
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| Abstract: |
| OBJECTIVE To design and synthesize the title compound.METHODS The title compound was synthesized from 2-butene-1,4-diol,via esterification,epoxidation,amination,then amidation with tetraiodoterebenzoyl chloride. RESULTS The structure was identified by MS, |
| Key words: nonionic x-ray contrast media epoxidation synthesis |
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