| 引用本文: | 柴雨柱1,2;陈国华1;王丽1;范琳1.抗抑郁药盐酸度洛西汀的合成[J].中国现代应用药学,2007,(3):209-211. |
| CHAI Yu-zhu1,2,CHENG Guo-hua1,WANG Li1,FAN Lin1.Synthesis of Antidepressant Drug Duloxetine Hydrochloride[J].Chin J Mod Appl Pharm(中国现代应用药学),2007,(3):209-211. |
|
|
| 摘要: |
| 目的合成盐酸度洛西汀并改进合成工艺。方法以2-乙酰噻吩为起始原料,经Mannich反应、还原、拆分、醚化、脱甲基、成盐等反应制得盐酸度洛西汀。结果所得产物经元素分析、紫外光谱、红外光谱、核磁共振谱及质谱等确证了结构。结论此工艺路线方法简便,原料易得,便于工业化生产。 |
| 关键词: 盐酸度洛西汀 抗抑郁药 合成 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Synthesis of Antidepressant Drug Duloxetine Hydrochloride |
|
CHAI Yu-zhu1,2,CHENG Guo-hua1,WANG Li1,FAN Lin1
|
| Abstract: |
| OBJECTIVE To synthesize duloxetine hydrochloride and optimize the process.METHODS Duloxetine hydrochloride was synthesized by steps of reaction(Mannich reaction,reduction,separation,etherication,demethylation and salification) from 2-acetylthiophene. RESU |
| Key words: duloxetine hydrochloride antidepressant drug synthesis |
