白藜芦醇对小鼠实验性胃黏膜损伤的保护作用

Protective Effect of Resveratrol on Experimental Gastric Mucosal Lesion in Mice

关键词:  白藜芦醇  胃黏膜损伤；无水乙醇；阿司匹林；吲哚美辛

Key words:  resveratrol  gastric mucosal lesion  ethanol absoute  aspirin  indomethacin

摘要:

目的研究白藜芦醇对小鼠实验性胃黏膜损伤的保护作用。方法制备小鼠无水乙醇型、阿司匹林型、吲哚美辛型胃黏膜损伤模型，测定胃黏膜损伤面积；测定血清中丙二醛和超氧化物歧化酶含量。结果白藜芦醇（25，50，100 mg·kg-1，ig）可剂量依赖性地抑制小鼠实验性胃黏膜损伤。白藜芦醇可使阿司匹林致小鼠胃黏膜损伤过程中血清中升高的丙二醛含量降低，可使降低的超氧化物歧化酶水平回升。结论白藜芦醇对小鼠实验性胃黏膜损伤具有保护作用，其作用机制可能与抗氧化作用有关。

Abstract:

OBJECTIVE To study the protective effect of resveratrol on experimental gastric mucosal lesion in mice.METHODS Make the model of gastric mucosal lesion in mice induced by ethanol absoute,aspirin and indomethacin.The area of gastric mucosal lesion in mice was determined.The contents of MDA and SOD of gastric tissue were measured.RESULTS The area of experimental gastric mucosal lesion in mice was inhibited after administration of resveratrol（25,50,100 mg·kg-1,ig）.The increase of MDA formation induced by aspirin was significantly decreased by resveratrol,and the decrease of SOD content of gastric mucosal tissue was elevated to normal level.CONCLUSION Resveratrol could possess protective effect on experimental gastric mucosal lesion in mice. Its mechanism may be related to antioxidative effect and improvement of SOD level to normal.