| 引用本文: | 钱云波，李轶，王永梅，吴扬.4-苄氧基-3-硝基-α-溴代苯乙酮的合成工艺改进[J].中国现代应用药学,2009,(1):38-39. |
| QIAN Yunbo, LI Yi, WANG Yongmei*，WU Yang.An Improved Produce for the Synthesis of 4-Benzyloxy-3-nitro-α-bromoacetophenone[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(1):38-39. |
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| 摘要: |
| 目的合成4-苄氧基-3-硝基-α-溴代苯乙酮，并进行工艺改进。方法以对羟基苯乙酮为原料，经过硝化、苄基化、溴代三步反应合成得到4-苄氧基-3-硝基-α-溴代苯乙酮，总收率达到45.2%。结果合成产物经熔点、红外光谱、核磁共振谱等分析确定结构正确;与文献报道一致。结论与其他文献方法比较,该法具有操作简单、收率高、污染小、成本低等特点，并可用于工业生产。 |
| 关键词: 4-苄氧基-3-硝基-α-溴代苯乙酮 福莫特罗 合成 |
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| An Improved Produce for the Synthesis of 4-Benzyloxy-3-nitro-α-bromoacetophenone |
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QIAN Yunbo, LI Yi, WANG Yongmei*，WU Yang
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| Abstract: |
| OBJECTIVE To synthesize 4-benzyloxy-3-nitro-α-bromoacetophenone. METHODS 4-benzyloxy-3-nitro-α-bromoacetophenone was synthesized in three steps starting from p-hydroxyacetophenone including nitration, benzylation, bromization, with overall yield of 45.2%. RESULTS The melting point and IR, 1-HNMR of the product were identical with that of the reported one. CONCLUSION The process can be easily controlled and is suitable for a scale production. |
| Key words: 4-benzyloxy-3-nitro-α-bromoacetophenone formoterol synthesis |
