阿卡波糖对老年糖耐量减低患者颈动脉内中膜厚度的影响

The Effect of Acarbose on Carotid Intimamedia Thickness in the Elderly Patients with Impaired Glucose Tolerance

关键词:  阿卡波糖；颈动脉内中膜厚度  糖耐量减低

Key words:  acarbose  carotid IMT  IGT

摘要:

目的观察阿卡波糖对老年糖耐量减低患者颈动脉内中膜厚度的影响。方法120例老年糖耐量减低患者分为两组：60例口服阿卡波糖50 mg，3次·d-1，持续1年，60例未服药，均随访1年。结果治疗后4周患者口服馒头餐后2 h血糖明显下降（P＜0.01）；1年后治疗组患者HbA1c明显减低（P＜0.05），平均颈动脉内中膜厚度增加治疗组明显低于对照组（P＜0.05）。结论阿卡波糖有效降低糖耐量减低患者餐后血糖，长期治疗可降低糖化血红蛋白，减缓动脉粥样硬化的发展。

Abstract:

OBJECTIVE To observe the effect of acarbose on carotid intimamedia thickness (IMT) in the elderly patients with impaired glucose tolerance (IGT). METHODS 120 cases of elderly patients with IGT were divided into two groups: 60 cases of oral Acarbose 50 mg, 3 times per day, continued one year,60 cases of no medication,all patients were followed up for 1 year. RESULTS Plasma glucose after steamed bread meal 2 hours (2hPG) was lowered obviously by treated for 4 weeks(P<0.01).After 1 year HbA1c was reduced(P<0.05).The average IMT increased in the treatment group was significantly lower than that of control group(P<0.05). CONCLUSION Acarbose reduced 2hPG in the elderly patients with IGT , long-term treatment can reduce HbA1c and delay the development of arteriosclerosis.