蒲薏颗粒对化疗荷瘤小鼠的增效减毒及免疫功能的影响

Study of Puyi Granule on Enhancing Effects of Chemotherapy and Reducing Toxicity and Immune Effect in Tumor-bearing Mice

关键词:  蒲薏颗粒  化疗  增效减毒  免疫调节

Key words:  Puyi granule  chemotherapy  toxicity-reducing  immunie regulation

摘要:

目的 研究蒲薏颗粒对荷瘤小鼠化疗增效、减毒及免疫调节作用。方法 建立小鼠恶性肿瘤转实体瘤模型，观察蒲薏颗粒与化疗药物合用对瘤体重量、血液白细胞(WBC)数、骨髓有核细胞数的影响；对肿瘤坏死因子(TNF-a)的影响以及对荷瘤小鼠免疫功能的影响。结果 蒲薏颗粒能增强化疗药物抑瘤作用、拮抗化疗药物对WBC及骨髓有核细胞的抑制；提高荷瘤小鼠TNF-a含量；增强免疫功能。结论 蒲薏颗粒对荷瘤小鼠具有化疗增效、减毒及免疫增强的作用。

Abstract:

OBJECTIVE To investigate the effects of Puyi granule for the chemotherapy, toxicity-reducing and immunization in mice implanted tumor. METHODS Build up the mice models with malignant tumor transferred by ascites tumor, and observe the effect on tumor weight, blood WBC and bone marrow nucleated cells when combined use Puyi granule and chemotherapeutic. Measure tumor necrosis factor and observe the immune effect in the mice models. RESULTS Puyi granule can strengthen antitumor activity of chemotherapeutic, antagonize the inhibition of chemotherapeutic to WBC and bone marrow nucleated cell, improve tumor necrosis factor, also can enhance immune function. CONCLUSION Puyi granule can increase the chemotherapeutic effect，reduce toxin, and enhance immune function．