醋酸地塞米松固体类脂纳米粒在小鼠体内的靶向性研究

The Targeted Properties of Dexamethasone Acetate Solid Lipid Nanoparticles in Mice

关键词:  醋酸地塞米松  药动学  组织分布  肺靶向

Key words:  dexamethasone acetate  pharmacokinetics  tissue distribution  lung-targeting

摘要:

目的 探讨醋酸地塞米松固体脂质纳米粒在小鼠体内的靶向性。方法 用HPLC测定生物样品中醋酸地塞米松的含量，比较醋酸地塞米松纳米粒和原药给药后在不同时间各脏器的药物含量、各脏器中药物的量占给药量的百分数及药动学参数，以评价醋酸地塞米松固体脂质纳米粒的靶向性。结果 在肺部，醋酸地塞米松纳米粒给药组的地塞米松含量、地塞米松量占给药量的百分数远高于原药给药组，两者的AUC值相差约16倍。结论 醋酸地塞米松固体脂质纳米粒在小鼠体内具有肺靶向性。

Abstract:

OBJECTIVE To study the targeted properties of dexamethasone acetate solid lipid nanoparticles in mice. METHODS A high performance liquid chromatographic (HPLC) assay for the determination of dexamethasone acetate in various tissues of mouse was employed in this study. Targeting properties were evaluated by comparing dexamethasone acetate content, percentage of dexamethasone acetate in various organs at different time, and pharmacokinetics parameters after administration of dexamethasone acetate solid lipid nanoparticles with those after administration of active compound. RESULTS Dexamethasone acetate content, percentage of dexamethasone acetate in lung were higher for the dexamethasone acetate - SLN group than that for the dexamethasone acetate - propylene glycol solution group. The difference of AUC between the two groups is 16 times. CONCLUTION Dexamethasone acetate solid lipid nanoparticles have targeting properties for lung in mice.