| 引用本文: | 褚建波1，王鸿1，李立安2.青藤碱凝胶剂透皮吸收的研究[J].中国现代应用药学,2009,(8):651-653. |
| CHU Jianbo1, WANG Hong1, LI Li'an2.Studies on Preparation and Transdermal Absorption through Rat Skin of Sinomenine Gel[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(8):651-653. |
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| 摘要: |
| 目的 研究青藤碱凝胶的制备方法及其皮肤通过量。方法 用卡巴姆934作为凝胶基质制备青藤碱凝胶，并采用HPLC测定药物的含量，采用TK-12A型透皮扩散池测定并比较其吸收量。结果 与羟丙基甲基纤维素凝胶相比，以卡巴姆934作为凝胶基质的青藤碱其经皮渗透效果较好。加入10%丙二醇对药物的经皮渗透影响不大。结论 青藤碱在以卡巴姆为基质的凝胶剂中具有较好的经皮渗透效果。 |
| 关键词: 青藤碱 卡巴姆934 经皮渗透 |
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| Studies on Preparation and Transdermal Absorption through Rat Skin of Sinomenine Gel |
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CHU Jianbo1, WANG Hong1, LI Li'an2
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| Abstract: |
| OBJECTIVE To study the preparation of sinomenine gel and transdermal absorption of gel through rat skin．METHODS Cabapol was used as gel material to prepare sinomenine gel. The permeability of sinomenine through rat skin was evaluated by using the TK-12A type diffusion cells. RESULTS Cabapol showed it was a suitable material for gel preparation and had larger permeation flux, and the effect of 10% propanediol in absorption of sinomenine from cabapol gel through rat skin was not obvious. CONCLUSION Sonimenine-containing gel with cabapol is suitable for transdermal delivery of drug. |
| Key words: sonimenine cabapol 934 transdermal |
