天银胶囊的制备工艺研究

Optimization of the Preparation Process of Tianyin Capsule

关键词:  天银胶囊  制备工艺  正交试验

Key words:  Tianyin capsule  preparation process  orthogonal experiment

摘要:

目的优选天银胶囊最佳制备工艺。方法以干膏收率及天麻素、总黄酮醇苷、萜类内酯含量为评价指标，进行正交试验；并进行制粒工艺研究。结果最佳提取工艺为：70℃时，70%乙醇提取2次，每次2.0 h，第1次加12倍量乙醇，第2次加8倍量乙醇；制粒工艺：75%乙醇作润湿剂，干膏粉∶辅料为1∶1。结论该工艺合理可行，适用于天银胶囊的制备。

Abstract:

OBJECTIVE To optimize preparation technology of Tianyin capsules. METHODS The extraction process was studied by orthogonal experimental design as guided by the yield of extract and the content of gastrodin, total flavonoids, ginkgolides as measuring index. Granulating conditions was studied. RESULTS The optimal extraction conditions: 70 ℃, and extracted 2 times by 70% ethanol. The time for each extraction was 2 h. The first time used 12 times alcohol, while the second used 8 times alcohol. Wetting agent was 75% alcohol, extraction powder∶adjuvant was 1∶1. CONCLUSION The preparation procedure is stable and feasible, it could be used for the preparation of Tianyin capsule.