| 引用本文: | 高晓荣1，李俊波2，魏文珑3*，常宏宏3.头孢哌酮中间体7-TMCA 盐酸盐合成工艺的改进[J].中国现代应用药学,2009,(10):832-834. |
| GAO Xiaorong1, LI Junbo2, WEI Wenlong3*, CHANG Honghong3.The Improvement of Synthetic Process for the Cefoperzaone Intermediate—7-TMCA·HCl[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(10):832-834. |
|
|
| 摘要: |
| 目的对抗生素头孢哌酮中间体7-TMCA 盐酸盐的合成方法进行改进。方法以1-甲基-5-巯基四氮唑和7-氨基头孢烷酸为原料，采用三氟化硼乙腈络合物催化合成7-TMCA盐酸盐，并通过均匀试验对合成工艺进行了优化。结果合成产物经熔点、IR确证，收率为92.0%。结论此方法收率高，产品纯度好，适合工业化生产。 |
| 关键词: 头孢哌酮 7-TMCA 盐酸盐 三氟化硼乙腈络合物 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| The Improvement of Synthetic Process for the Cefoperzaone Intermediate—7-TMCA·HCl |
|
GAO Xiaorong1, LI Junbo2, WEI Wenlong3*, CHANG Honghong3
|
| Abstract: |
| OBJECTIVE The synthetic method of the cefoperazone intermediate-7-TMCA HCl was improved in the paper. METHODS 1-methyl-5-mercapto-tetrazole and 7-amino-cephalosporin acid (7-ACA) was used as raw material and acetonitrile-boron trifluoride complex was utilized as catalyst to synthesize 7-TMCA HCl. At the same time the synthetic process was optimized by the uniform experiment method. RESULTS The product was identified by melting point and IR spectra, the yield can reach up to 92.0%. CONCLUSION The product was obtained with much higher yield and good purity. It was suitable for industrial applications. |
| Key words: cefoperazone 7-TMCA·HCl acetonitrile-boron trifluoride complex |
