| 引用本文: | 郭舜民，林绥，林文津，齐一萍.雷公藤硫氰酸基内酯醇的半合成研究[J].中国现代应用药学,2009,(11):919-920. |
| GUO Shunmin, LIN Sui, LIN Wenjin, QI Yiping.Study on the Semi-synthesis of Tripthiocyanatolide[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(11):919-920. |
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| 摘要: |
| 目的合成雷公藤硫氰酸基内酯醇。方法以雷公藤甲素为起始原料，通过亲核取代反应生成雷公藤硫氰酸基内酯醇。结果总收率为79.5%，目标化合物的结构经IR、1H-NMR、MS等方法确证。结论利用半合成技术开发高效低毒的新药是一条重要途径 |
| 关键词: 雷公藤甲素 雷公藤硫氰酸基内酯醇 半合成 |
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| Study on the Semi-synthesis of Tripthiocyanatolide |
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GUO Shunmin, LIN Sui, LIN Wenjin, QI Yiping
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| Abstract: |
| OBJECTIVE To synthesize the title compound. METHODS Tripthiocyanatolide was semi-synthesized by triptolide, which was a convenient starting material, through the reaction of nucleophilic substitution. RESULTS The total yield was 79.5%. The target compound was identified by IR, 1H-NMR and MS. CONCLUSION It′s very important to develop a new product with high effect and low toxicity by making use of 2-step synthesis technology. |
| Key words: triptolide tripthiocyanatolide semi-synthesis |
