布地奈德治疗慢性阻塞性肺疾病的疗效与安全性研究

Study of Curative Effect and Security about Budesonide on Chronic Obstructive Pulmonary Disease

关键词:  慢性阻塞性肺疾病  布地奈德  甲强龙

Key words:  chronic obstructive pulmonary disease  budesonide  methylprednisolone

摘要:

目的观察布地奈德雾化吸入治疗中重度慢性阻塞性肺疾病（COPD）急性加重期的疗效及安全性。方法选择65例COPD急性加重期患者，随机分为治疗组33例，对照组32例。在给予常规治疗的同时，治疗组雾化吸入布地奈德2 mg·d-1，tid。对照组静脉点滴甲强龙40 mg，qd。记录两组患者入院时及治疗后第1、3、5天的呼吸困难评分及肺功能、动脉血气分析及药物不良反应情况。结果两组患者治疗后呼吸困难评分及肺功能、动脉血气分析均明显改善。两组间比较无显著差异，治疗组不良反应发生率明显低于对照组。结论布地奈德雾化吸入治疗中重度COPD急性加重期的疗效与静脉点滴甲强龙相似，不良反应发生率低。可作为COPD急性加重期激素治疗的有效选择。

Abstract:

OBJECTIVE To observe the curative effect and security about budesonide pulverization in the moderate-severe and acute exacerbation of chronic obstructive plumonary disease(COPD).METHODS Sixty-five patients of acute exacerbation of COPD were randomly divided into treatment group with 33 cases,and control group with 32 cases.On the base of the routine therapies,treatment group was given budesonide pulverization,2 mg every time,three times a day,and control group ivgtt intravenouslly guttae methylprednisolone,40 mg every time,one time a day.The dyspnea score at the beginning of admitting and 1,3,5 dyas after the treatment,pulmonary function,arterial blood gas analysis and adverse reactions of drug were recorded.RESULTS The two group patients' dyspnea scores,pulmonary function,and arterial blood gas analysis were greatly improved.The differences between the two groups were not statistical.On the adverse reactions of drug,the treatment group were less than the control group.CONCLUSION The c…更多urative effect about budesonide pulverization in the moderate-severe and acute exacerbation of COPD was similar with methylprednisolone by ivgtt intravenouslly guttae,and incidences rate of adverse drug reaction was in the low level,and may be regarded as the effective treatment on the patients with acute exacerbation of COPD.