猫爪草多糖对环磷酰胺致小鼠免疫低下模型免疫功能的影响

Effects of Radix Ranunculi Ternati Polysaccharide on Immunological Function of the Immunosuppressional Model Mice Induced by Cyclophosphamide

关键词:  猫爪草多糖  环磷酰胺  小鼠免疫抑制模型  免疫功能

Key words:  Radix Ranunculi Ternati polysaccharide  cyclophosphamide  immunosuppressive model mice  immunological function

摘要:

目的 探讨猫爪草多糖对环磷酰胺致小鼠免疫抑制模型免疫功能的作用特点。方法 应用环磷酰胺建立免疫抑制模型，观察大、中、小剂量猫爪草多糖对模型小鼠腹腔巨噬细胞吞噬功能、溶血素和溶血空斑形成以及淋巴细胞转化的影响。结果 大、中剂量猫爪草多糖可显著提高免疫抑制小鼠吞噬百分率和吞噬指数；中剂量猫爪草多糖和香菇多糖组可显著促进溶血素的形成；大、中、小剂量猫爪草多糖和香菇多糖均可显著促进溶血空斑的形成、促进淋巴细胞转化。结论 猫爪草多糖可明显改善环磷酰胺致免疫抑制小鼠免疫功能。

Abstract:

OBJECTIVE　To explore the effects of the Radix Ranunculi Ternati polysaccharide(RRTP) on immunological function of the immunosuppressive model mice induced by cyclophosphamide(CY). METHODS Establish the immunosuppressive model mice by using injection of CY. The effects of RRTP on model mice were observed following these indexes, such as peritoneal macrophage phagocytosis function, formation of hemolysin or plaque, and lymphocyte transformation. RESULTS The large and medium dose RRTP group can increase phagocytosis percentage and phagocytic index of peritoneal macrophages in immunosuppressive model mice significantly. The medium dose RRTP and lentinan group can promote the formation of hemolysin significantly. The large, medium and small-dose RRTP, and lentinan group can promote the formation of plaque and lymphocyte transformation significantly. CONCLUSION The RRTP can obviously improve immunological function of the immunosuppressive model mice induced by CY.