莫西沙星与左氧氟沙星治疗呼吸道感染的Meta分析

Meta-analysis on the Moxifloxacin and Levofloxacin in the Treatment of Respiratory Tract Infection

关键词:  莫西沙星  左氧氟沙星  呼吸道感染  Meta分析

Key words:  moxifloxacin  levofloxacin  respiratory tract infection  Meta-analysis

摘要:

目的 比较莫西沙星与左氧氟沙星在治疗呼吸道感染的有效性和安全性。方法 应用RevMan 5软件对国内1998-2008年发表的运用莫西沙星治疗呼吸道感染的随机对照试验进行meta分析，左氧氟沙星为对照组，结果指标包括临床总有效率、细菌清除率、不良反应发生率。结果 检索到18个试验，包括1 392例患者。莫西沙星总有效率优于对照组[RR 2.24，95% CI(1.64，3.07)；P<0.000 01]；细菌清除率优于对照组[RR 2.35，95% CI(1.58，3.49)；P<0.000 1]；不良反应发生率可能少于对照组。结论 现有的证据表明，莫西沙星在治疗呼吸道感染的疗效优于左氧氟沙星。不良反应可能少于左氧氟沙星或两者无差异。

Abstract:

OBJECTIVE To compare the effectuality and safety of the moxifloxacin and levofloxacin in the treatment of respiratory tract infection. METHODS Using meta-analysis to evaluate the effectuality and safety of the moxifloxacin from the randomized controlled trai1s(RCTs) published from 1998 to 2008 in Chinese journals with RevMan 5. The control group were given levofloxacin, the outcome we compared included: total efficacy rata, bacterial eradication rates, adverse effect rates. RESULTS 18 RCTs and 1 392 patients which were included meta-analysis indicated that the total effective rate of moxifloxacin is superior to control[RR 2.24, 95% CI(1.64, 3.07); P<0.000 01]; the bacterial eradication rates of moxifloxacin is superior to control[RR 2.35, 95% CI(1.58, 3.49); P<0.0001]; the adverse effect rates of moxifloxacin is probablely smaller than control. CONCLUSION The effectuality of the moxifloxacin in the treatment of respiratory tract infection is better than levofloxacin. The adverse effect rates of moxifloxacin is probablely smaller than control, or no difference between the two groups.