大剂量尖吻蝮蛇凝血酶对家兔血浆纤维蛋白原的影响

Effect of Large Doses Hemocoagulase Agkistrodon Acutus on the Plasma Fibrinogen Level in Rabbits

关键词:  尖吻蝮蛇凝血酶  纤维蛋白原  家兔

Key words:  hemocoagulase Agkistrodon acutus  fibrinogen  rabbit

摘要:

目的 探讨大剂量尖吻蝮蛇凝血酶对家兔血浆纤维蛋白原的影响，为临床应用提供参考。方法 家兔耳缘静脉注射不同剂量的尖吻蝮蛇凝血酶，并于给药后不同时间检测其血浆纤维蛋白原含量。结果 0.2~1.0 U·kg^-1剂量的尖吻蝮蛇凝血酶可导致家兔血浆纤维蛋白原明显下降(P<0.05)，下降速度及下降幅度与剂量成正相关。剂量≥0.4 U·kg^-1时家兔血浆纤维蛋白原开始出现耗竭，剂量≥0.8 U·kg^-1时所有家兔血浆纤维蛋白原均出现耗竭。结论 大剂量尖吻蝮蛇凝血酶具有明显降低家兔血浆纤维蛋白原的作用。

Abstract:

OBJECTIVE To study the effect of large doses hemocoagulase Agkistrodon acutus on the fibrinogen level in rabbit, to provide a reference for clinical application. METHODS The 30 rabbits were randomly divided into 5 groups and were injected with different doses of hemocoagulase Agkistrodon acutus respectively, the plasma fibrinogen level were examined after administration. RESULTS The hemocoagulase Agkistrodon acutus with 0.2-1.0 U·kg^-1 doses resulted in the significant decrease of the plasma fibrinogen level of rabbits. The depletion of plasma fibrinogen was first occurred in individual rabbit at 0.4 U·kg^-1 doses, and while the doses were increased above 0.6 U·kg^-1(include 0.6 U·kg^-1). The depletion of plasma fibrinogen was occurred in all rabbits. CONCLUSIONS The large doses hemocoagulase Agkistrodon acutus have significant effects of decreasing the plasma fibrinogen level of rabbits.