急进与久居高原者血糖、血脂和电解质变化对复方甲基异噁唑片药动学影响

Effects of Blood Glucose, Lipid and Dielectric on SMZCo Pharmacokinetics After Short- and Long-time Exposure to High-altitude

关键词:  高原低氧  药动学  复方甲基异噁唑片  血糖  血脂  电解质

Key words:  high altitude  pharmacokinetics  SMZCo  blood glucose  lipid  dielectric

摘要:

目的 研究急进与久居高原者血糖、血脂和电解质含量变化对复方甲基异噁唑片药动学影响。方法 采用高效液相色谱法测定平原、急进高原和久居高原3组2个群体健康汉族男性青年志愿者口服单剂量复方甲基异噁唑片前后15个时间点血浆药物浓度。应用全自动生化仪测定3组血糖、血脂和电解质含量。采用DAS 2.0和SPSS 13.0统计软件计算3组受试者口服复方甲基异噁唑片后磺胺甲噁唑的药动学和血糖、血脂和电解质参数。结果 急进高原组和久居高原组受试者的药动学参数Ke、MRT、t_1/2、Cl与平原组相比有显著性差异，急进高原组t_1/2、V与久居高原组相比有显著性差异。久居高原组血糖和血脂含量高于平原组和急进高原组，载脂蛋白含量A则显著减少(P均<0.01)。急进高原组K含量增加，与平原组相比有统计学意义(P<0.05)。久居高原组Cl和Ca与急进高原组相比差异显著(P分别<0.05和0.01)，急进高原组与久居高原组P均低于平原组(P<0.01)。葡萄糖(GLU)和胆固醇(TCH)与t_1/2正相关，APOA与t_1/2和V/F负相关(P<0.01)。K和Ca与AUC正相关(P分别小于0.05和0.01)，与Cl/F和V/F负相关(P分别小于0.05和0.01)。Cl与V/F负相关(P<0.05)。结论 急进与久居高原者血糖、血脂和电解质含量变化对复方甲基异噁唑片药动学有显著影响。

Abstract:

OBJECTIVE To study the effects of blood glucose, lipid and dielectric on SMZCo pharmacokinetics after short- and long-time exposure to high altitude. METHODS The young volunteers of healthy male Chinese Hans were divided into three groups: the plain group, the rapid ascent group and the adaptation group. All subjects in this study were treated with a single dose of SMZCo tablets, and their plasma concentration of SMZ were determined by HPLC and the blood glucose, lipid and dielectric were determined by automatic biochemistry instrument. Datas obtained were analyzed by DAS 2.0 and SPSS 13.0 software. RESULTS There were significant differences in pharmacokinetics parameters of Ke, MRT, t_1/2 and Cl comparing the rapid ascent group and the adaptation group with the plain group, and in that of t_1/2 and V comparing the adaptation group with the rapid ascent group. The blood glucose, and lipid were higher and the APOA and APOB were lower in the adaptation group than the rapid ascent group and plain group (P<0.01). The K were significant raised up in the rapid ascent group comparing with the plain group (P<0.05). There was significant difference between the adaptation group and the rapid ascent group in Cl and Ca contents. The P contents was stepped down in the rapid ascent group and the adaptation group. There were the positive correlation between TCH, GLU and t1/2(P<0.05 or 0.01) and the negative correlation between APOA and t_1/2, Vz/F(P<0.01) and between Cl and Vz/F (P<0.05). K, Ca were the positive correlation with AUC (P<0.05 or 0.01) and the negative correlation with Clz/F and Vz/F(P<0.05 or 0.01). CONCLUSION The blood glucose, lipid and dielectric have significant effects on AUC, t_1/2, Cl and Vz/F of pharmacokinetics of SMZ at high altitude.