P糖蛋白表达对HIV-1蛋白酶抑制剂在体内吸收与分布的影响

The Role of P-Glycoprotein Expression on Absorption and Distribution of HIV-1 Protease Inhibitors

关键词:  P糖蛋白  分布  屏障

Key words:  P-glycoprotein  distribution  barrier

摘要:

目的 通过介绍体内各屏障高度表达的P糖蛋白外排作用对HIV-1蛋白酶抑制剂的影响，探讨如何通过有效调节P糖蛋白，优化对艾滋病患者的治疗。方法 查阅国外文献进行总结和归纳。结果 综述了P糖蛋白表达对HIV-1蛋白酶抑制剂在体内吸收、分布的影响。 结论 P糖蛋白一定程度地阻碍了HIV-1蛋白酶抑制剂在体内的吸收和分布，通过抑制P糖蛋白的活性，可以增加HIV-1蛋白酶抑制剂的化学疗效，未来艾滋病的治疗，P糖蛋白抑制剂的选择和使用将是一项艰巨的任务。

Abstract:

OBJECTIVE By introducing the efflux function of P-glycoprotein(P-gp), the way to optimize the treatment of HIV-1 infection by modulation of P-gp was discussed. METHODS Searching and summarizing literatures about HIV-1 protease inhibitor and P-gp. RESULTS The effect of P-gp expression for HIV-1 protease inhibitor absorption and distribution was summarized. CONCLUSION P-gp can hamper the absorption and distribution of HIV-1 protease inhibitor. The therapeutic effect of HIV-1 protease inhibitors can be improved by modulating P-gp properly, however, the selection and use of P-gp inhibitor will be an arduous mission in the future.