正交法优选复方骨碎补接骨片提取工艺的研究

Optimum Extraction on Compound Gusuibujiegu Tablet by Orthogonal Design

关键词:  

Key words:  compound Gusuibujiegu tablet  HPLC  extraction  orthogonal design method

摘要:

目的 筛选复方骨碎补接骨片的提取工艺。方法 以提取时间、溶剂量、提取次数、药材粒度为可变因素，选用L9 (34)表进行试验。结果 最佳提取工艺为将药材混匀粉碎，过20目筛，用10倍量水提取2次，每次1 h。结论 该提取工艺经济、可行。

Abstract:

OBJECTIVE To select the best extraction process of compound Gusuibujiegu tablet．METHODS The time of extract, amount of solvent, times of extract and raw material for medicine granularity were choosed as variable factors. Orthogonal design method L9 (34) was used．RESULTS The optimum extraction was to smach the mixed raw material and pass through 20 mesh sieve, then extract twice with 10 times as much water, 1 h for each time, 20 items have sieved, withdraws with 10 times of quantity water 2 times, each time 1 h. CONCLUSION This method is simple，accurate and controllable.